Label-free multi-aptamer DNA nanowire electrochemical sensor based on HCR for highly sensitive detection of ATP

Key Points

• Detection of ATP is achieved with a sensitivity significantly higher than traditional methods, indicating improved capabilities.
• The sensor utilizes a label-free approach combined with multi-aptamer technology, enhancing specificity and accuracy.
• Employing a hybridization chain reaction (HCR) in the sensor design allows for real-time monitoring of ATP levels using electrochemical detection.
• Results support potential applications in disease diagnostics and biomarker identification, requiring further validation in clinical settings.