Nature-inspired chalcone-functionalized paracetamol derivatives as potential anticancer leads: synthesis, biological evaluation, apoptotic mechanisms, and in silico docking studies

Key Points

• Chalcone-functionalized paracetamol derivatives demonstrate significant anticancer activity in various assays, highlighting their therapeutic potential.
• The study reports a promising lead with a 70% decrease in cell viability for specific cancer cell lines after treatment.
• Biological evaluation included apoptosis mechanisms supported by in silico docking studies, enhancing our understanding of interactions at the molecular level.
• These findings indicate that further development of these compounds may enable new cancer treatment strategies, warranting additional research.