Integrated analysis of single-cell and bulk transcriptomes reveals the prognostic value of polyamine metabolism biomarkers and immune microenvironment features in gastric cancer

Key Points

• Polyamine metabolism serves as a crucial prognostic marker in gastric cancer, influencing therapeutic decisions and outcomes.
• The analysis indicates clear links between cellular heterogeneity and immune microenvironment characteristics, with implications for treatment strategies.
• Observational analysis of single-cell and bulk transcriptomes reveals novel biomarkers related to gastric cancer prognosis.
• These findings may inform clinical practices, indicating that targeting polyamine metabolism could improve patient outcomes.

Abstract