Investigating TGF-β1-induced renal fibrosis in a parallel computational-experimental spheroid system

Key Points

• TGF-β1 significantly induces renal fibrosis within the experimental model, showing notable cellular changes.
• Analysis demonstrated a clear relationship between TGF-β1 exposure and increased fibrosis scores, particularly at 48 hours.
• This observational analysis employed both computational and experimental spheroids to better understand fibrosis progression.
• Findings may enable targeted interventions for renal fibrosis, yet further validation across different systems is needed.