Genetic and epigenetic insights into perioperative neurocognitive disorders: a narrative review

Key Points

• Neurocognitive disorders are increasingly understood through genetic and epigenetic lenses, with a significant focus on underlying mechanisms.
• Key biomarkers relate to genetic factors and epigenetic modifications that contribute to perioperative cognitive decline, affecting recovery.
• Narrative review synthesizes various studies linking genetic predispositions and epigenetic changes to neurocognitive disorders post-surgery.
• Findings suggest targeting these genetic and epigenetic factors might enhance prevention and treatment strategies for cognitive disorders.