Pyrogallol-rich supramolecular hydrogels with enzyme-sensitive microdomains for controlled topical delivery of hydrophobic drugs

Key Points

• Controlled delivery of hydrophobic drugs is achieved using enzyme-sensitive supramolecular hydrogels.
• The hydrogels' design helps in targeted topical applications while minimizing systemic exposure.
• Assessment employed a method that highlights the role of microdomains in drug release kinetics.
• Future work may enhance the effectiveness of topical formulations in clinical settings.