Lidocaine‐induced apoptosis of gingival fibroblasts: participation of cAMP and PKC activity

Key Points

• Lidocaine significantly induces apoptosis of gingival fibroblasts, indicating a direct cellular effect.
• The mechanism involves activation of cAMP and protein kinase C (PKC) pathways in fibroblasts' response.
• Assessment using cell viability assays demonstrates lidocaine's effectiveness at varying concentrations.
• These findings highlight lidocaine's potential cellular impact, warranting further investigation on implications for dental procedures.