Pharmacokinetic and pharmacodynamic modeling of marbofloxacin administered alone and in combination with tolfenamic acid in goats

Key Points

• Marbofloxacin's effectiveness varies with co-administration of tolfenamic acid, impacting treatment efficiency in goats.
• Peak plasma concentration of marbofloxacin is significantly altered when combined with tolfenamic acid, emphasizing critical dosage considerations.
• Pharmacokinetic and pharmacodynamic modeling reveals complex interactions between drugs, crucial for veterinary practices.
• Findings support the need for tailored dosage regimens to optimize veterinary treatment protocols, focusing on goat health.