Water-based coupling of amino acids for sustainable solid-phase peptide synthesis

Key Points

• The study reveals a novel method for solid-phase peptide synthesis using water-based coupling agents for amino acids.
• A significant reduction in solvent use is achieved, enhancing sustainability and reducing environmental impact.
• Experimental assessments indicate comparable efficiency in peptide yields compared to traditional methods, optimizing resource use.
• Potentially significant for reducing the ecological footprint of peptide synthesis, encouraging broader adoption in the field.