Comparative Safety and Efficacy of Bendamustine Versus Fludarabine/Cyclophosphamide Prior to Chimeric Antigen Receptor- T cell Therapy: A Systematic Review and Meta-Analysis

Key Points

• Bendamustine shows comparable safety and efficacy to fludarabine/cyclophosphamide before CAR-T therapy.
• The analysis includes data from multiple studies assessing therapeutic outcomes across various populations.
• This systematic review and meta-analysis examined outcomes like response rates and toxicities with specific comparative treatments.
• Understanding these treatments' effectiveness can guide critical decisions in administering CAR-T therapy; more studies are needed.