Andrographolide analogues are agonists of the estrogen receptor alpha in vitro and in vivo

Key Points

• Andrographolide analogues significantly activate the estrogen receptor alpha, enhancing its activity in various cellular contexts.
• In vitro experiments showed that these analogues lead to a measurable increase in receptor activation levels observed through specific assays.
• Analysis across multiple biological systems confirmed that the agonistic properties of these compounds are consistent in vivo, suggesting stability and efficacy.
• Supports further exploration of andrographolide analogues as potential treatment options for conditions related to estrogen signaling.