Survival Impact of Primary Tumor Surgery in De Novo Stage IV Breast Cancer: A Propensity-Matched Cohort Study with Prognostic Nomogram Development

Key Points

• Primary tumor surgery improves survival outcomes in stage IV breast cancer, highlighting its potential impact on patient prognosis.
• The study identified a significant survival benefit of approximately 30% among patients who underwent surgery compared to those who did not.
• Conducted as a propensity-matched cohort study, the research controlled for potential confounding variables, ensuring robust findings.
• These results could change clinical practices, emphasizing the role of surgery in advanced breast cancer management.