Model-Based ATG Dosing Optimization in Αβ Haplo-HSCT: Improved Pre-HSCT Exposure Consistency and Viral Infection Analysis

Key Points

• Improved ATG dosing resulted in enhanced exposure consistency, which is crucial for patient outcomes.
• Tracking viral infections yielded valuable insights, directly impacting treatment strategies post-HSCT.
• Model-based dosing optimization was applied to pre-HSCT preparation, enhancing personalization of therapy.
• This analysis highlights the necessity for tailored interventions in haplo-HSCT to reduce complications.