March 3, 2026Open Access

Long-term cognitive outcomes and persistent executive dysfunction in LGI1 autoimmune encephalitis

Key Points

Cognitive outcomes improve after immunotherapy, yet executive dysfunction often remains a long-term deficit.
Older age is a significant predictor of poorer cognitive outcomes, indicating an age-related vulnerability.
Observational analysis investigates cognitive changes following immunotherapy for LGI1 autoimmune encephalitis in older patients.
Findings suggest a need for targeted interventions for older individuals to improve long-term cognitive recovery.

Abstract

Cognitive outcomes in LGI1 autoimmune encephalitis improve after immunotherapy, yet executive dysfunction frequently persists as a long-term deficit. Older age independently predicts poorer outcomes, suggesting that age-related vulnerability may limit recovery.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Cite this study

Shir et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69a76017c6e9836116a2c80b — DOI: https://doi.org/10.1016/j.jns.2026.125789

Authors

Dror Shir

Orna Aizenstein

Yael Paran

Journals

Journal of the Neurological Sciences

Actions

Institutions

Tel Aviv University

Tel Aviv Sourasky Medical Center

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Long-term cognitive outcomes and persistent executive dysfunction in LGI1 autoimmune encephalitis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion