Spontaneous Conception After Integrated Traditional Chinese and Western Medicine Treatment for Chronic Endometritis with Recurrent Implantation Failure: A Case Report and Literature Review

Abstract: Recurrent implantation failure (RIF) is a challenging issue in in vitro fertilization and embryo transfer (IVF-ET). Chronic endometritis (CE) is one of the causes of RIF. For patients with CE and RIF, antibiotic therapy is currently the first-line and most widely used treatment. Nevertheless, it often fails to achieve the desired therapeutic outcomes. This case report presents a woman diagnosed with CE and RIF, who did not achieve pregnancy after four embryo transfers involving a total of seven embryos during IVF-ET treatment. However, after receiving a integrated therapy of Traditional Chinese Medicine (TCM) and antibiotics for CE, the patient achieved a spontaneous conception and subsequently delivered a healthy baby. This case suggests that an integrated approach of TCM and antibiotics may represent a safe and effective therapeutic strategy for patients with CE and RIF, offering a potential alternative to overcome the limitations of conventional antibiotic therapy alone. This finding warrants further investigation. Keywords: chronic endometritis, recurrent implantation failure, endometrial receptivity, integrative Chinese and Western medicine therapy