March 3, 2026Open Access

Equity and Transportability of Plasma ATN Phenotypes in a Population-Representative U.S. Aging Cohort

Key Points

Plasma ATN biomarkers reveal significant equity gaps across demographic subgroups, indicating varying access to healthcare.
A 12-percentage-point sensitivity disparity was noted, emphasizing the challenges in implementing these biomarkers fairly.
Validation using fairness metrics is essential for the clinical deployment of plasma ATN biomarkers across diverse populations.
Addressing education-dependent effect modification is critical to ensure equitable healthcare outcomes.

Abstract

Plasma ATN biomarkers demonstrate significant equity gaps and differential transportability across demographic subgroups. The 12-percentage-point sensitivity disparity and education-dependent effect modification highlight barriers to equitable implementation. Population-based validation with fairness metrics should be prerequisite for clinical deployment.

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Authors

Emmanuel Fle Chea

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University of Minnesota

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Equity and Transportability of Plasma ATN Phenotypes in a Population-Representative U.S. Aging Cohort

Key Points

Abstract

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Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

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Discussion

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