Targeting extrachromosomal DNA in human cancers

Key Points

• Extrachromosomal DNA significantly contributes to oncogenes in human cancers, altering tumorigenesis patterns.
• Key evidence shows that higher levels of extrachromosomal DNA correlate with increased genomic instability and more aggressive tumors.
• Assessment using genomic sequencing data reveals patterns of extrachromosomal DNA involvement across various cancer types.
• Findings highlight the need for targeted therapies aimed at extrachromosomal DNA to improve cancer treatment.