Extra-helical allosteric binding site of apomorphine in ADGRG6

Key Points

• The allosteric binding site identified enhances our understanding of ligand binding dynamics.
• Key evidence shows that apomorphine operates at an extra-helical site, influencing receptor activity.
• Analysis focused on molecular interactions within ADGRG6 receptors in a lab setting.
• Findings highlight potential therapeutic avenues for targeting ADGRG6 through allosteric modulation.