Liquid biopsy of plasma and urinary CfDNA differentiates glioma recurrence from radiation brain necrosis in preclinical models

Key Points

• Glioma recurrence can be differentiated from radiation brain necrosis using circulating free DNA (cfDNA) analysis.
• The study shows significant accuracy with cfDNA biomarkers in identifying tumor presence, with implications for treatment.
• Using a preclinical model, the analysis leverages liquid biopsies from both plasma and urine to obtain results.
• Findings suggest the need for further exploration of cfDNA as a non-invasive tool for glioma diagnosis.