The Ang2:Tie2 Axis Regulates Pulmonary Vascular Endothelial Cell Injury and Activation Responsible for the Development of Idiopathic Pneumonia Syndrome Following Allogeneic Blood and Marrow Transplantation

Puntos clave

• The Ang2:Tie2 axis significantly impacts pulmonary vascular endothelial cell injury, contributing to pathology.
• During the process, the dysfunction of endothelial cells is evidenced by increased activation markers following transplantation.
• Assessment utilizing endothelial injury markers shows notable changes in the pulmonary vascular system post-transplant.
• These findings highlight potential therapeutic targets for preventing idiopathic pneumonia syndrome; further studies are needed.