Porcine Cardiac Blood processed Kansui Radix alleviates PTZ-induced epileptic damage in mice via the bidirectional regulation of GABRA1 and cGMP/PKG signaling pathway

Key Points

• Kansui Radix alleviates epileptic damage in mice through bidirectional regulation of GABRA1 and cGMP/PKG pathways, enhancing neuroprotection.
• In experiments, treatment with Kansui Radix showed a significant decrease in seizure frequency measured over 14 days post-treatment.
• Analysis involved assessing the regulatory effects of Kansui Radix on key signaling pathways associated with epilepsy.
• This work highlights the need for further investigation into Kansui Radix as a promising candidate for pharmacological intervention in epilepsy.