Glutamine alleviates radiation-induced intestinal injury in rats via the mTOR/Notch1 axis

Key Points

• Glutamine provides significant protection against radiation-induced intestinal injury, promoting recovery mechanisms.
• Protection is associated with modulation of the mTOR/Notch1 signaling pathway, which helps alleviate Notch1 overactivation.
• The study utilized a rat model to examine the protective effects of glutamine following radiation exposure.
• Findings underscore glutamine's promise as a therapeutic agent, though further investigation may be needed for clinical application.

Abstract