Anoctamin 5 mutation leads to abnormal bone homeostasis of GDD by regulating AMPK-dependent glucose metabolism

Key Points

• Abnormal bone homeostasis in GDD is linked to glucose metabolism alterations mediated by AMPK activation.
• The findings suggest that AMPK plays a crucial role in the pathophysiology of GDD-related bone issues.
• This analysis emphasizes the importance of metabolic pathways, particularly glucose metabolism, in GDD.
• Therapeutic strategies targeting AMPK-dependent glucose metabolism may improve conditions related to GDD.

Abstract