March 3, 2026Open Access

PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cells

Key Points

PFAS exposure triggers pro-inflammatory cytokines, which are regulated by PPARγ signaling pathways.
Activation of PPARγ can reduce the inflammatory response caused by PFAS in lung epithelial cells.
The study highlights the importance of PPARγ for controlling inflammation from environmental toxins.
These findings suggest potential therapeutic strategies targeting PPARγ for lung inflammation caused by PFAS.

Abstract

These findings demonstrate that PFAS-induced pro-inflammatory cytokines is mediated, at least in part, through PPARγ signaling, and that pharmacological activation of PPARγ signaling can attenuate PFAS-triggered pro-inflammatory cytokine responses in lung epithelial cells.

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Cite this study

Shaikh et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69a76068c6e9836116a2d1ff — DOI: https://doi.org/10.3389/fphar.2026.1779345

Authors

Sadiya Bi Shaikh

Md Imam Faizan

Khursheed Ul Islam

Journals

Frontiers in Pharmacology

Actions

Institutions

University of Rochester Medical Center

Harbor–UCLA Medical Center

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

PPAR-gamma regulates PFAS-mediated proinflammatory cytokines in lung epithelial cells

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion