Unmasking the Risks: Infection-Related Adverse Events after CAR-T and BiTE Therapy in Hematologic Malignancies. a Systematic Review and Meta-Analysis

Key Points

• Infection-related adverse events were found to be significantly increased after CAR-T and BiTE therapies, highlighting safety concerns.
• The analysis reveals that incidence rates for infections varied, affecting treatment outcomes across different hematologic malignancies.
• A systematic review and meta-analysis across multiple studies assessed outcomes related to infection risks post-therapy.
• These findings emphasize the need for vigilance and monitoring for infection-related complications in CAR-T and BiTE therapy.