Post-Transplant Cyclophosphamide Is Associated with Early Expansion of Regulatory T cells and Monocytic Myeloid-Derived Suppressor Cells after Allogeneic Hematopoietic Cell Transplantation

Key Points

• Regulatory T cells and monocytic myeloid-derived suppressor cells expand significantly after treatment.
• Expansion of regulatory T cells occurs within days of cyclophosphamide administration.
• Observational analysis highlighting immunological changes following transplantation and cyclophosphamide.
• These findings may enhance strategies for improving tolerance in transplant settings.