Lead Exposure Triggers DNA Damage in TK6 Cells Via Alteration of DNA Repair Gene Expression and Hypermethylation of Ku80 Promoter Region

Key Points

• DNA damage occurs due to lead exposure, impacting cell viability and function.
• Ku80 is significantly hypermethylated, leading to decreased repair gene expression.
• Observational analysis across cell cultures identifies the DNA repair pathways affected by lead exposure.
• These findings highlight the potential genomic risks associated with environmental lead exposure.