Autologous Stem Cell Transplantation for Refractory Juvenile-Onset Systemic Sclerosis

Key Points

• Improved outcomes observed in juvenile-onset systemic sclerosis patients after autologous stem cell transplantation, with significant symptom reduction.
• Patients showed a 60% improvement in skin thickness measured by the modified Rodnan skin score within six months.
• Evaluation using a multi-center registry over a two-year follow-up period confirmed the effectiveness of the intervention.
• Highlights the need for further trials to validate findings and explore long-term safety in broader populations.