Overactivation of TRPV4 by toosendanin induces intracellular calcium overload and colonic toxicity

Key Points

• Calcium overload directly correlates with colonic toxicity triggered by toosendanin.
• Notable evidence shows that increased intracellular calcium levels are linked to TRPV4 activation.
• The analysis involved examining the impact of toosendanin on cellular calcium signaling in colonic cells.
• Further investigation is needed to understand the long-term implications of TRPV4 overactivation.