Combination of oximes as experimental therapeutic approach to organophosphates poisonings: a critical review

Key Points

• Oximes may improve therapeutic outcomes in organophosphate poisoning, providing better enzyme reactivation.
• Evidence highlights that specific combinations of oximes have shown increased efficacy over single compounds in treatment.
• Critical review of existing literature evaluated various oxime combinations and their effectiveness in toxicology contexts.
• Results imply that re-evaluating therapeutic combinations could significantly enhance the management of organophosphate exposure.