Role of BM and PB Next Generation Sequencing (NGS) MRD Vs. BM Multichannel Flow Cytometry (MFC) MRD Pre/Post-Allogeneic HCT in Predicting Outcomes for Children and Young Adults (CAYA) with B-ALL: Planned Analysis of the Ptctc ONC1401 Trial

Key Points

• Molecular techniques like NGS and flow cytometry provide critical insights into minimal residual disease.
• The analysis focuses on comparing MRD detection pre and post-allogeneic hematopoietic cell transplantation.
• Utilizing advanced methods, the study evaluates patient prognoses and their implications for future treatments.
• The findings support the need for improved predictive strategies, emphasizing further validation in broader cohorts.