Differential expression of complement Properdin and Factor H in the placentae and umbilical cords of mothers with Preeclampsia, Gestational Diabetes Mellitus and Recurrent Pregnancy Loss

Key Points

• Elevated properdin levels may increase inflammatory response in conditions like preeclampsia and gestational diabetes.
• Low Factor H along with high C3 and C5 levels indicates complement activation issues in the placenta.
• Analysis performed on placental and umbilical cord samples from mothers experiencing pregnancy complications.
• Findings highlight the possible roles of complement proteins in gestational complications, requiring further investigation.

Abstract