March 3, 2026Open Access

Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

Key Points

Sepsis-induced acute lung injury is alleviated by Xuanqing Hefa Formula, targeting pyroptosis mechanisms.
XQHF shows significant inhibition of the NLRP3/Caspase-1 pathway, with results from in vivo and in vitro experiments revealing efficacy.
The analysis highlights multiple active constituents working synergistically to suppress inflammatory responses.
Inhibition of pyroptosis by XQHF suggests a promising treatment strategy; further exploration is warranted.

Abstract

Our results suggest that the therapeutic effects of XQHF may be attributed to the synergistic actions of its multiple active constituents, which collectively suppress the inflammatory cascade and attenuate pyroptosis, thereby alleviating lung injury. Furthermore, both in vivo and in vitro experiments demonstrated that XQHF modulates sepsis-induced acute lung injury, at least in part, through the inhibition of the NLRP3/Caspase-1-dependent pyroptosis signaling pathway.

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Cite this study

Lei et al. (Tue,) studied this question.

www.synapsesocial.com/papers/69a760a2c6e9836116a2d953 — DOI: https://doi.org/10.3389/fimmu.2025.1709586

Authors

Can Lei

Xia Yuan

Xiaodong Li

Journals

Frontiers in Immunology

Actions

Institutions

Capital Medical University

Beijing University of Chinese Medicine

Tongren Hospital

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion