Hypercapnic acidosis affects in vitro lung infection response in a pathogen-specific manner

Key Points

• Lung inflammation is prolonged due to hypercapnic acidosis, impacting how the body fights infections.
• Different pathogens are affected in various ways by hypercapnic acidosis, influencing their persistence in the lungs.
• The compromised barrier function in the lungs results from prolonged exposure to hypercapnic acidosis.
• Findings suggest that targeting the inflammatory response may improve outcomes in lung infections exacerbated by hypercapnia.

Abstract