Establishment of accurate estimation equations for area under the concentration curves using simultaneous limited sampling for extended-release tacrolimus and mycophenolic acid in kidney transplant recipients

Key Points

• The equation C0-C1-C3-C6 estimates both TAC-ER and MPA AUC accurately, showing strong correlation with R² over 0.95.
• Validation demonstrates the efficacy of the LSS technique for estimating pharmacokinetics in a clinical setting.
• This analysis supports the use of simultaneous limited sampling for effective medication monitoring in renal transplant patients.
• Implementation of these estimation equations could reduce healthcare costs and improve patient management for kidney transplant recipients.

Abstract