March 3, 2026Open Access

ETS Homologous Factor Drives Endothelial Dysfunction in Diabetes-Related Erectile Dysfunction via Regulating SPRY1 Ubiquitination and NOS3 Autophagy

Key Points

Endothelial dysfunction is exacerbated by the modulation of SPRY1 and degradation of NOS3.
Key evidence shows increased SPRY1 stabilization linked to dysregulated endothelial function in diabetes.
This analysis focuses on the interaction between Ehf, SPRY1, and NOS3 in a diabetes context.
Identifying these molecular targets may lead to new treatment strategies for erectile dysfunction caused by diabetes.

Abstract

Ehf exacerbates DMED by disrupting penile endothelial function through SPRY1 stabilization and NOS3 degradation. These findings present novel molecular targets for potential therapeutic strategies in DMED.

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Discussion

Authors

Chunhui Liu

Ning Liu

Zonghao You

Journals

The World Journal of Men s Health

Actions

Institutions

University of British Columbia

Southeast University

Zhongda Hospital Southeast University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

ETS Homologous Factor Drives Endothelial Dysfunction in Diabetes-Related Erectile Dysfunction via Regulating SPRY1 Ubiquitination and NOS3 Autophagy

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study