Deficiency of primate-specific TFDP3 causes male infertility with oligoasthenoteratozoospermia in humans and cynomolgus monkeys

Key Points

• Male infertility linked to deficiency in the primate-specific gene TFDP3, affecting sperm quality.
• Patients exhibited oligoasthenoteratozoospermia, characterized by poor sperm count and morphology.
• The observational analysis included both human cases and cynomolgus monkey models to study genetic impacts.
• Findings highlight the critical role of TFDP3 in male fertility, indicating areas for deeper genetic exploration.