Photoacoustic imaging and biodistribution analysis of trimethyl chitosan-stabilized ZnO nanoparticles embedded in nanofiber scaffolds for diabetic wound healing

Key Points

• Wound healing was enhanced in diabetic models, applying nanofiber scaffolds incorporating ZnO nanoparticles.
• The research demonstrated effective biodistribution and localization of nanoparticles at the wound site.
• Photoacoustic imaging was utilized to track the behavior of nanoparticles over time within the wound environment.
• Findings suggest that the unique combination of trimethyl chitosan and ZnO may optimize diabetic wound care strategies.