Hyaluronic acid-ethylenediamine-cinnamic acid attenuates IBS-D via regulating 5-hydroxytryptamine signaling pathway, intestinal barrier and gut microbiota

Key Points

• Hyaluronic acid and cinnamic acid significantly improve symptom management in IBS-D.
• Key evidence shows a substantial modulation in the 5-hydroxytryptamine signaling pathway leading to improved gut function.
• The approach utilized an observational analysis focusing on the interaction between gut microbiota and intestinal barriers.
• The findings support potential therapeutic roles for these compounds in managing intestinal disorders, particularly IBS-D.