Population Pharmacokinetic Modeling of Thiotepa in Pediatric and Young Adult HCT Recipients

Key Points

• Dosing recommendations for thiotepa are optimized for pediatric and young adult populations, enhancing treatment efficacy.
• Key pharmacokinetic parameters were identified in population analysis across multiple patients, improving precision.
• The observational analysis utilized pharmacokinetic data from pediatric and young adult hematopoietic cell transplant recipients.
• This work highlights the need for tailored dosing strategies in young patients, emphasizing population pharmacokinetic considerations.