Characterization of Breakthrough Invasive Fungal Infections in Allogeneic Hematopoietic Cell Transplant Recipients Receiving Antifungal Prophylaxis

Key Points

• Breakthrough invasive fungal infections were identified in patients receiving antifungal prophylaxis, indicating a potential treatment failure.
• In the cohort analysis, 22% of patients developed infections despite undergoing prophylaxis, highlighting the challenges in management.
• The observational analysis evaluated infection types and pathogens in allogeneic hematopoietic cell transplant recipients to understand this clinical issue.
• Findings emphasize the need for improved antifungal strategies to prevent infections in vulnerable transplant populations.