Diagnostic and therapeutic approaches to polypharmacy and unknown drug overdose in the intensive care unit: A narrative review

Key Points

• Polypharmacy poses significant risks, particularly in patients experiencing drug overdose in the intensive care unit.
• Evidence suggests that comprehensive diagnostic approaches can enhance treatment efficacy for drug-related issues.
• Assessment of therapeutic interventions underscores the variability in patient responses to overdose treatment protocols.
• This review emphasizes the need for tailored strategies to manage polypharmacy-related complications in critical care settings.