March 3, 2026Open Access

De-escalating radiotherapy in pathologic complete response oral cancer after neoadjuvant immunochemotherapy: equal survival, better life, and a biomarker guide

Key Points

Equal survival observed despite omitting adjuvant radiotherapy after pCR in oral cancer patients.
Adjuvant radiotherapy was omitted in a patient cohort achieving pathologic complete response after neoadjuvant immunotherapy.
Assessment used an integrated TP53/B-cell biomarker model for personalizing the treatment approach.
Highlights the potential for improved patient quality of life while maintaining effective cancer care.

Abstract

Adjuvant radiotherapy omission with maintenance immunotherapy appears to be a safe and patient-beneficial strategy for OSCC patients achieving pCR after NICT. The integrated TP53/B-cell biomarker model provides preliminary evidence for personalizing this de-escalation approach.

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Authors

Zhenjie Guan

Qiongqiong Yu

Journals

Frontiers in Oncology

SHILAP Revista de lepidopterología

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Institutions

First Affiliated Hospital of Zhengzhou University

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De-escalating radiotherapy in pathologic complete response oral cancer after neoadjuvant immunochemotherapy: equal survival, better life, and a biomarker guide

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

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Discussion

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