Overall, ES confirmed the etiology of hereditary anemia in 2.4% (5/207) of genetically diagnosed NIHF cases. Hereditary anemias, therefore, represent a distinct and clinically relevant subset of ES-diagnosed NIHF cases. ES should be considered first line in fetuses with NIHF, as common non-genetic causes such as fetomaternal hemorrhage, infectious etiologies, and alloimmunization are excluded. It is also indicated when fetal anemia is suspected, particularly in the setting of elevated MCA Dopplers with a negative evaluation for common hemoglobinopathies and nongenetic etiologies.
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Mona M. Makhamreh
Stephanie M. Rice
Kavya Shivashankar
Clinical Therapeutics
University of Illinois Urbana-Champaign
Baylor College of Medicine
University of Illinois Chicago
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Makhamreh et al. (Sun,) studied this question.
www.synapsesocial.com/papers/69a760d3c6e9836116a2df1e — DOI: https://doi.org/10.1016/j.clinthera.2026.01.002