Secreted luciferases as a minimally invasive 3R-compliant tool for accurate monitoring of tumor burden

Key Points

• Accurate monitoring of tumor burden is possible using secreted luciferases, enhancing traditional methods.
• The method shows a significant reduction in invasiveness, aligning with 3R principles of animal research.
• Assessment as a minimally invasive tool introduces potential for more ethical cancer research.
• This approach may enable improved tracking and treatment adjustments in cancer management strategies.