Beyond Engraftment: Predictors and Consequences of Graft Failure in Pediatric Hematopoietic Cell Transplantation for Non-Malignant Diseases

Key Points

• Graft failure rates were notably high, reaching up to 30% in specific populations treated for non-malignant diseases.
• Key predictors identified include age at transplantation and type of underlying disease, which significantly affect outcomes.
• Analysis of pediatric hematopoietic cell transplantation provides insights into the graft failure mechanisms and their implications.
• Findings underline the need for tailored strategies in managing pediatric patients undergoing transplantation to improve graft survival.