Synthesis of thiophene-appended pyrazolines via citrus juice-assisted cyclocondensation: Characterization, crystal studies, computational analysis, and anti-angiogenic potential

Key Points

• The anti-angiogenic activity of the synthesized compounds shows significant promise in biomedical applications.
• A total of four new thiophene-appended pyrazolines were synthesized using a citrus juice-assisted method.
• Characterization techniques confirmed the structures and crystallinities of the synthesized pyrazolines.
• Computational analysis supports the favorable interactions of these compounds in biological pathways.