Oleuropein restores oocyte competence during SIRT1 inhibition via SIRT1/NRF2-mediated redox and metabolic reprogramming in porcine oocytes

Key Points

• Oocyte competence is restored through oleuropein treatment, enhancing cellular function and viability.
• Findings indicate a significant increase in oocyte quality under SIRT1 inhibition after treatment with oleuropein.
• Research utilized porcine oocytes to explore the mechanisms of SIRT1 and NRF2 in redox and metabolic changes.
• These findings may enable new approaches for fertility treatments, highlighting the need for further investigations.