Exercise training reinforces the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation for ventricular ectopy and myocardial infarction injury

This study investigated the synergistic effect of early bone marrow-derived mesenchymal stem cells (BM-MSC) transplantation and endurance training on exercise-induced ventricular ectopy, myocardial infarction-induced injury and cardiac function in rats. 90 male Wistar rats (7-8 weeks) randomly distributed following groups, 1: Healthy control (HC, n = 15), 2: Sham (Sham, n = 15), 3 Myocardial infarction (MI, n = 15), 4: Myocardial infarction with BM-MSC transplantation (MI-SC, n = 15), 5: Myocardial infarction with Endurance training (MI-ET, n = 15) and 6: Myocardial infarction with Endurance training and BM-MSC transplantation (MI-ET + SC, n = 15). Myocardial infarction was induced by permanent obstruction of the cardiac left anterior descending artery. One day after MI induction, 1 × 10