A novel microprotein MUCP1 promotes colorectal cancer metabolic reprogramming by regulating mitochondrial succinate transport

Key Points

• Metabolic reprogramming is promoted by microprotein MUCP1 in colorectal cancer, enhancing tumor growth.
• Colorectal cancer cells displayed increased succinate transport due to elevated microprotein levels.
• Assessment of mitochondrial function revealed significant changes in succinate levels linked to MUCP1 regulation.
• Highlights the potential for targeting microproteins like MUCP1 in cancer therapies for better outcomes.